| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Neonatal RPR Screen (serum) with Reflex to Titer
MessageThis testing is intended for use on infants less than 30 days of age.
Test Code
NEO RPR
Alias/See Also
Performed at MMC Micro for NOCO facilities
Performed at SQL for remaining facilities, Test Code 907295
Performed at SQL for remaining facilities, Test Code 907295
CPT Codes
86593, 86592
Preferred Specimen
1 mL serum from a serum separator tube (SST)
Minimum Volume
0.5 mL serum from a serum separator tube (SST)
Instructions
See link below for specimen details, methodology, setup schedule and reference ranges.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Methodology
charcoal flocculation
Setup Schedule
Evenings: Monday through Friday
Nights: Monday through Sunday
Nights: Monday through Sunday
Report Available
1-2 days
Reference Range
Non-reactive
Clinical Significance
The nontreponemal test performed on the neonate should be the same type of nontreponemal test performed on the mother.
Congenital syphilis should be considered if the neonatal serum quantitative nontreponemal serologic titer is fourfold (or greater) higher than the mother’s titer at delivery (e.g., maternal titer = 1:2, neonatal titer ≥1:8 or maternal titer = 1:8, neonatal titer ≥1:32).
Conducting a treponemal test (e.g., syphilis EIA/CIA and TP-PA) on neonatal serum is not recommended because it is difficult to interpret, as passively transferred maternal antibodies can persist for >15 months. Commercially available IgM tests are not recommended.
Reference: CDC Sexually Transmitted Infections Treatment Guidelines, 2021.
Congenital syphilis should be considered if the neonatal serum quantitative nontreponemal serologic titer is fourfold (or greater) higher than the mother’s titer at delivery (e.g., maternal titer = 1:2, neonatal titer ≥1:8 or maternal titer = 1:8, neonatal titer ≥1:32).
Conducting a treponemal test (e.g., syphilis EIA/CIA and TP-PA) on neonatal serum is not recommended because it is difficult to interpret, as passively transferred maternal antibodies can persist for >15 months. Commercially available IgM tests are not recommended.
Reference: CDC Sexually Transmitted Infections Treatment Guidelines, 2021.
Performing Laboratory
Sonora Quest Laboratories or McKee Medical Center Microbiology Laboratory
Additional Information
Neonatal RPR Screen (serum) with Reflex to Titer
