Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, CSF

Test Code

MOGCSF w/RFLX

Quest Code

36954

Alias/See Also

Transverse Myelitis Antibody,NMO Spectrum Disorder,Myelin oligodendrocyte glycoprotein,MOG-IgG,LETM antibody,Optic Neuritis Antibody,ADEM antibody,NMOSD

CPT Codes
86362

Includes

If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86362).

Preferred Specimen

2 mL CSF collected in a plastic screw-cap vial

Minimum Volume

0.5 mL

Transport Temperature

Frozen

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Visible particulate matter

Methodology
Cell-based Immunofluorescence Assay

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Sets up 1 day a week.

Report Available

Reports in 3 to 7 days.

Reference Range

MOG Ab CBA, CSF	Negative
MOG Ab Titer, CSF	<1:2 titer

Clinical Significance

Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.