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Cocci Complement Fixation
Test CodeCCF
Alias/See Also
Performed by SQL Test Code:1063
CPT Codes
86635
Preferred Specimen
1.5 mL serum from a serum seperator tube (SST)
Minimum Volume
0.75 mL
Instructions
Centrifuge as soon as possible after clot formation.
See link below for specimen details, methodology, setup schedule and reference ranges.
See link below for specimen details, methodology, setup schedule and reference ranges.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Methodology
Complement Fixation
Setup Schedule
Days: Monday through Thursday
Report Available
3-8 days
Reference Range
<1:2
Clinical Significance
Coccidioidomycosis, also known as San Joaquin Valley fever, is a systemic fungal infection endemic to Arizona and other parts of the southwestern United States. Approximately 60% of infections are asymptomatic. Of the 40% who develop symptoms, most will have an acute febrile "flu-like" illness starting 7-28 days (average 10-16 days) after exposure and most patients will recover completely. The main symptoms are fever, pleuritic chest pain, cough, malaise, headache, myalgia, night sweats and loss of appetite. Five percent of patients may develop metapulmonary dissemination to the meninges, bones, joints, and subcutaneous and cutaneous tissues within the first few weeks to months after the onset of primary infection. Complement Fixation (CF), a quantitative IgG assay, is useful as a prognostic test. Results are expressed as titers, such as 1:2 or 1:8. A titer of 1:16 or greater has been frequently associated with extrapulmonary dissemination.
Performing Laboratory
Sonora Quest Laboratories
Additional Information
Coccidioides Complement Fixation