Porphyrins, Fractionated, Quantitative, 24-Hour Urine

Message

Non-Interface testing, place order in Quanum

Test Code

PORPHTU

Quest Code

729

Alias/See Also

729

CPT Codes
84120

Includes

Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

2 mL urine from a 24-hour urine collected in a 5 g sodium carbonate container or no preservative container - protected from light

Minimum Volume

1 mL

Other Acceptable Specimens

No preservative - See Collection Instructions

Instructions

24-hour urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred.
Collection with no preservative is acceptable, if properly refrigerated and light protected.
24-hour total volume must be provided on the test requisition.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Not protected from light • pH <4.0

Methodology
High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M.; P.M. Sets up 5 days a week.

Reference Range

Uroporphyrin I	4.1-22.4 mcg/24 h
Uroporphyrin III	0.7-7.4 mcg/24 h
Heptacarboxyporphyrin	≤3.3 mcg/24 h
Hexacarboxyporphyrin	≤10 mcg/24 h
Pentacarboxyporphyrin	≤4.6 mcg/24 h
Coproporphyrin I	7.1-48.7 mcg/24 h
Coproporphyrin III	11.0-148.5 mcg/24 h
Total Porphyrins	35.0-210.7 mcg/24 h

Clinical Significance

Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.