17 Hydroxypregnenolone

Test Code
PREGN17


Quest Code
8352


Alias/See Also
8352
67652P


CPT Codes
84143

Preferred Specimen
2 mL serum collected in a red-top tube (no gel)


Minimum Volume
0.4 mL


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric • Serum Separator Tubes (SST®) • Received room temperature


Methodology
Chromatography/Mass Spectrometry

Setup Schedule
Night


Limitations
Infants with 21-hydroxylase deficiency may present with non-elevated results.


Reference Range
Adult Males ≤700 ng/dL

Adult Females, Pre-Menopausal
Mid Follicular 38-378 ng/dL
Surge 33-583 ng/dL
Mid Luteal 70-470 ng/dL

Pediatric Male and Female
<30 days ≤3013 ng/dL
1-11 months ≤869 ng/dL
1 year ≤557 ng/dL
2 years ≤487 ng/dL
3 years ≤541 ng/dL
4 years ≤561 ng/dL
5 years ≤564 ng/dL
6 years ≤561 ng/dL
7 years ≤549 ng/dL
8 years ≤569 ng/dL
9 years ≤590 ng/dL
10 years ≤594 ng/dL
11 years ≤629 ng/dL
12 years ≤666 ng/dL
13 years ≤678 ng/dL
14 years ≤706 ng/dL
15 years ≤735 ng/dL
16 years ≤739 ng/dL
17 years ≤756 ng/dL


Clinical Significance
17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.


Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.