A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
17 Hydroxypregnenolone
Test CodePREGN17
Quest Code
8352
Alias/See Also
Pregnenolone, 17-Oh
CPT Codes
84143
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.4 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days
Refrigerated: 5 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric • Serum Separator Tubes (SST®) • Received room temperature
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Night
Limitations
Infants with 21-hydroxylase deficiency may present with non-elevated results.
Reference Range
Adult Males | ≤700 ng/dL |
Adult Females, Pre-Menopausal
Mid Follicular | 38-378 ng/dL |
Surge | 33-583 ng/dL |
Mid Luteal | 70-470 ng/dL |
Pediatric Male and Female
<30 days | ≤3013 ng/dL |
1-11 months | ≤869 ng/dL |
1 year | ≤557 ng/dL |
2 years | ≤487 ng/dL |
3 years | ≤541 ng/dL |
4 years | ≤561 ng/dL |
5 years | ≤564 ng/dL |
6 years | ≤561 ng/dL |
7 years | ≤549 ng/dL |
8 years | ≤569 ng/dL |
9 years | ≤590 ng/dL |
10 years | ≤594 ng/dL |
11 years | ≤629 ng/dL |
12 years | ≤666 ng/dL |
13 years | ≤678 ng/dL |
14 years | ≤706 ng/dL |
15 years | ≤735 ng/dL |
16 years | ≤739 ng/dL |
17 years | ≤756 ng/dL |
Clinical Significance
17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130