Lysozyme (Muramidase)

Test Code

Quest Code

Alias/See Also

CPT Codes

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.5 mL

Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 15 days
Frozen: 18 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic


FDA Status

Setup Schedule
P.M. Sets up 2 days a week.

Report Available
Reports in 1 day.

Reference Range
5.0-11.0 mcg/mL

Clinical Significance
Lysozyme in the serum is primarily due to the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign and malignant processes. Serum lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and levels decrease with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.

Performing Laboratory
Quest Diagnostics Chantilly Nichols Institute
14225 Newbrook Dr.
Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.