Lysozyme (Muramidase)

Test Code

LYSOZYME

Quest Code

619

Alias/See Also

619

CPT Codes
85549

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Instructions

Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 15 days
Frozen: 18 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic

Methodology
Enzymatic

FDA Status
LDT

Setup Schedule

P.M. Sets up 2 days a week.

Report Available

Reports in 1 day.

Reference Range

5.0-11.0 mcg/mL

Clinical Significance

Lysozyme in the serum is primarily due to the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign and malignant processes. Serum lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and levels decrease with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.

Performing Laboratory
Quest Diagnostics Chantilly Nichols Institute
14225 Newbrook Dr.
Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.