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Multiple Sclerosis Panel 2
Test CodeMULTSC
Quest Code
7085
Alias/See Also
MS Panel 2
CPT Codes
82040, 82042, 82784 (x2), 83873, 83916
Includes
Myelin Basic Protein, Oligoclonal Bands (IgG), CSF, and IgG Synthesis Rate/Index, CSF
Preferred Specimen
4.2 mL CSF in a sterile screw cap container and 3 mL serum
Patient Preparation
Requires Serum and CSF for proper testing.
Minimum Volume
2 mL CSF • 1.5 mL serum
Instructions
Please see the individual tests for specific specimen requirements and stabilities.
For the Oligoclonal Bands and IgG Synthesis Rate assays, both CSF & Serum are required specimens. It is preferred that the collection date and time be the same for both: however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20° C and send frozen samples to the laboratory on dry ice.
For the Oligoclonal Bands and IgG Synthesis Rate assays, both CSF & Serum are required specimens. It is preferred that the collection date and time be the same for both: however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20° C and send frozen samples to the laboratory on dry ice.
Transport Temperature
Transport Serum and CSF Frozen in Irreplaceble Specimen Bag
Specimen Stability
Room temperature: 8 hours
Refrigerated: days
Frozen: 21 days
Refrigerated: days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Xanthochromia • RBCs • Hemolysis in CSF
Methodology
Isoelectric Focusing (IEF) • Nephelometry • Radioimmunoassay (RIA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Reference Range
See Laboratory Report
Clinical Significance
Useful in the diagnosis of Multiple Sclerosis.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
