Coxsackie A Antibodies, Serum

Test Code

COXAAB

Quest Code

37477

Alias/See Also

37477X

CPT Codes
86658 (x6)

Includes

Coxsackie Antibodies A2, A4, A7, A9, A10, A16

Preferred Specimen

2 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Methodology
Complement Fixation (CF)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tue-Sat; Report available: 2-5 days

Limitations

Culture does not usually support growth of coxsackie A viruses.

Reference Range

Coxsackie A2 Ab	<1:8 titer
Coxsackie A4 Ab	<1:8 titer
Coxsackie A7 Ab	<1:8 titer
Coxsackie A9 Ab	<1:8 titer
Coxsackie A10 Ab	<1:8 titer
Coxsackie A16 Ab	<1:8 titer

Interpretive Criteria

<1:8	Antibody Not Detected
≥1:8	Antibody Detected

Clinical Significance

Panel currently includes testing against A-2, 4, 7, 9, 10, and 16 antigens. Although there is cross-reactivity among the enteroviruses by CF, most healthy people do not have titers >1:8. Therefore, detectable titers, especially those >1:32, should be considered diagnostic. Confirmed serodiagnosis is made by demonstration of a four-fold change in titers between acute and convalescent sera.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.