A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Estrone
Test CodeESTRONE
Quest Code
23244
Alias/See Also
23244
CPT Codes
82679
Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.25 mL
Instructions
Specify age and sex on test request form
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 30 days
Frozen (-20° C): 30 days
Frozen (-70° C): 1 year
Refrigerated: 30 days
Frozen (-20° C): 30 days
Frozen (-70° C): 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST) • Gross hemolysis
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night
Reference Range
Adult | |
Male | ≤68 pg/mL |
Female | |
Follicular Phase | 10-138 pg/mL |
Luteal Phase | 16-173 pg/mL |
Postmenopausal Phase | ≤65 pg/mL |
Pediatric
Age | Male (pg/mL) | Female (pg/mL) |
Pre-pubertal (1-9 years) | <10 | ≤34 |
10-11 years | ≤12 | ≤72 |
12-14 years | ≤28 | ≤75 |
15-17 years | ≤64 | ≤188 |
Clinical Significance
Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130