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Estriol, LC/MS, Serum
MessageNon-Interface
Test Code
ESTRIOL
Quest Code
34883
Alias/See Also
34883
CPT Codes
82677
Preferred Specimen
0.5 mL serum collected in a red-top tube (no-gel)
Minimum Volume
0.3 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night
Reference Range
Adult Males | ≤0.18 ng/mL | ||
Adult Females (non-pregnant) | ≤0.21 ng/mL | ||
Pregnancy | |||
First Trimester | ≤2.50 ng/mL | ||
Second Trimester | ≤9.60 ng/mL | ||
Third Trimester | ≤14.60 ng/mL |
Clinical Significance
The placenta converts DHEA-S produced by the fetal adrenals to Estriol and other estrogens. Estriol is useful in assessing the fetal adrenals and placenta during pregnancy. More commonly, Estriol is one of the maternal serum biochemical markers used to screen for common chromosomal trisomies, especially Down syndrome.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130