JC Polyoma Virus DNA, Quantitative, Real-Time PCR, CSF

Test Code
JCVPCRQTSF


Quest Code
16442


CPT Codes
87799

Preferred Specimen
0.7 mL CSF collected in a sterile, leak-proof container


Minimum Volume
0.3 mL


Transport Temperature
Frozen


Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days


Methodology
Real-Time Polymerase Chain Reaction

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Daily; Report available: 1 day


Reference Range
JC Virus DNA, QN PCR, CSFNot Detected (IU/mL)
JC Virus DNA, QN PCR, CSFNot Detected (Log IU/mL)


Clinical Significance
JC Polyoma Virus is the cause of Progressive Multifocal Leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. PML is a particular concern for individuals infected with the human immunodeficiency virus. Quantification of JC virus DNA is based upon the real-time PCR amplification and detection of JCV genomic DNA. Reportable range is 50 to 50,000,000 IU/mL (1.70 to 7.70 Log IU/mL).


Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.