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Beta-2 Transferrin, Body Fluid
MessageMust specify body fluid type in Cerner.
Test Code
B2TRANS BF
Quest Code
10640
CPT Codes
86335
Preferred Specimen
0.5 mL body fluid collected in a sterile leak-proof container
Minimum Volume
0.2 mL
Other Acceptable Specimens
See Collection Instructions
Instructions
• Indicate specimen source.
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 15 days
Refrigerated: 30 days
Frozen: 60 days
Refrigerated: 30 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens collected with additives
Methodology
Electrophoresis • Immunofixation
FDA Status
FDA Approved
Setup Schedule
A.M.
Reference Range
Not detected
Clinical Significance
Presence of Beta-2 Transferrin (B2T) in nose and ear secretions is indicative of cerebrospinal fluid (CSF) leakage. B2T is used as a marker of CSF leakage for the diagnosis of rhinorrhea or otorrhea as a result of head trauma, tumor, congenital malformation, surgery etc. Prompt diagnosis and localization helps localization and life-threatening CNS infections.
Performing Laboratory
Quest Diagnostics Chantilly Nichols Institute
14225 Newbrook Dr.
Chantilly, VA 20151-2228
