OB Antibody Titer

Message

Red blood cell antibody titers are most often requested on patients during pregnancy and are ordered on these patients by requesting the OB Antibody Titers Order. The blood bank will send the patient’s sample to Vitalant or American Red Cross for testing.

Test Code

TITEROB

CPT Codes
86886 - Lab Coombs Indirect Titer

Preferred Specimen

6 mL red non-gel and 16 mL EDTA tubes

Instructions

If known, enter the name of the specific antibody or antibodies to be sent for titration (ex. Anti-D).

Transport Temperature

Refrigerated

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gel separator tube used
Hemolysis

Report Available

Routine 1-2 days
ASAP within 24 hours
STAT within 8 hours

Clinical Significance

Titrations can provide information about the relative amount of antibody present or about the relative strength of antigen expression on the red cells. Numerous IgG antibodies have been reported to cause hemolytic disease of the fetus and newborn (HDFN) most common of which are anti-D, anti-K, anti-c, anti-C and anti-Fya. The titer for the alloimmunized pregnancy has been the mainstay in decision making and should be established in the first trimester to serve as a baseline. The pregnancy should be followed with sequential titer. A difference of two dilutions or a titer of 32 or higher is considered a significant result.

Performing Laboratory
BCCH
Vitalant Immunohematology Reference Laboratory
1524 W. 14th St., Ste 120, Tempe, AZ 85281

BLMC
Vitalant Immunohematology Reference Laboratory
10585 Armstrong Ave. Mather, CA 95655

OCH
American Red Cross Immunohematology Reference Laboratory
3838 Dewey Avenue Omaha, NE 68105

WMC
Vitalant Immunohematology Reference Laboratory
144 Grand Ave. Billings, MT 59102

WyMC and NCMC
Vitalant Immunohematology Reference Laboratory 717 Yosemite Street Denver, CO 80203

Additional Information
Vitalant Antibody Titer
American Red Cross - OCH only

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.