RPR (with reflex to Titer and TPPA as indicated)

Message

Performed at SQL or MMC Micro

Test Code

RPR

Alias/See Also

Syphilis
VDRL

CPT Codes
86592

Preferred Specimen

1 mL serum from a serum separator tube (SST). Centrifuge as soon as possible after clot formation.

Minimum Volume

0.5 mL

Instructions

See link below for specimen details, methodology, setup schedule and reference ranges for SQL sites.

Transport Temperature

Refrigerated

Specimen Stability

Ambient: 24 hours
Refrigerated: 7 days
Frozen: 30 days

Methodology
RPR: charcoal flocculation
TPPA: particle agglutination

Setup Schedule

Evenings: Monday through Friday
Nights: Monday through Sunday

Report Available

1-2 days

Reference Range

Non-reactive

Clinical Significance

The traditional algorithm (RPR Screen w/Reflex RPR Titer and TP-PA) is designed to detect acute infections. Non-treponemal antibodies rise early during the course of infection making the RPR screen a highly sensitive test for active infections. However, the RPR screen is not specific for syphilis, therefore false positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy, and thus all RPR reactive results needed to be confirmed with a treponemal test (i.e., TP-PA). The RPR screen may also be negative in early primary syphilis, treated cases, and late-stage disease, in cases like these the reverse algorithm should be considered.

Performing Laboratory
Sonora Quest Laboratories
McKee Medical Center Microbiology Laboratory

Additional Information
RPR Screen w/Reflex RPR Titer and TP-PA

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.