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Levetiracetam (Keppra) LCMSMS [if Brivaracetam is prescribed]
Test CodeLEVM LCMSMS
Quest Code
15142
CPT Codes
80177
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Patient Preparation
Collect at trough level (i.e. immediately prior to next dose).
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, EDTA (royal blue-top) tube, sodium heparin (green-top) tube, or 3.2% sodium citrate (light blue-top) tube
Instructions
Collect in red-top tube (no gel). Avoid use of Serum Separator Tube (SST®) as the drug may be adsorbed into the gel.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 28 days
Frozen: 60 days
Refrigerated: 28 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum separator tube (SST)
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat
Report Available
Report available: 2-3 days
Reference Range
12.0-46.0 mcg/mL
Toxic level is not well established. Interpretation should include a clinical evaluation.
Toxic level is not well established. Interpretation should include a clinical evaluation.
Clinical Significance
Levetiracetam is an anticonvulsant used as adjunct therapy to treat adult partial seizures. As multiple anticonvulsants are administered, it is important to monitor its level to (1) optimize therapy, (2) assure compliance, and (3) to avoid toxicity.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Valencia |
| 8407 Fallbrook Ave, Suite 100 |
| West Hills, CA 91304-3226 |
