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Itraconazole
Test CodeItraconazole, LC/MS/MS
Quest Code
94092
CPT Codes
80189<br><strong>This test is not available for New York patient testing.</strong>
Includes
Itraconazole and OH-Itraconazole
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tubes (SST) • Other body fluid
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Thurs, Sat; Report available: 2-5 days
Reference Range
| Itraconazole (trough) localized infection | >0.5 mcg/mL |
| Itraconazole (trough) systemic infection | >1.0 mcg/mL |
The total of Itraconazole and its active metabolite, hydroxyl-itraconazole, is 1-4 mcg/mL
Clinical Significance
The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted
Performing Laboratory
| MedFusion |
| 2501 South State Hwy 121, Suite 1100 |
| Lewisville, TX 75067-8188 |
