Topiramate

Test Code
TPIR


Quest Code
30965


CPT Codes
80201<br><strong>This test is not available for New York patient testing</strong>

Preferred Specimen
1 mL serum collected in a red-top tube (no gel)


Patient Preparation
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state

Minimum Volume
0.5 mL


Other Acceptable Specimens
Plasma collected in: Sodium heparin lead-free (tan-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube


Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state.


Transport Temperature
Room temperature


Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel barrier/serum separator tube (SST)


Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Tues-Sat; Report available: 5 days


Reference Range
Therapeutic Range
Dose (mg)Peak (mcg/mL)Trough (mcg/mL)
1006.5-9.24.5-6.6
20012.0-16.08.0-12.0
40020.0-30.014.0-20.0


Clinical Significance
Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.


Performing Laboratory
MedFusion
2501 South State Highway 121
Suite 1100
Lewisville, TX 75067-8188



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.