Sex Hormone Binding Globulin (SHBG)

Test Code

SEXTEBG

Quest Code

30740

CPT Codes
84270

Preferred Specimen

0.7 mL serum

Minimum Volume

0.5 mL

Instructions

Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For Patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Plasma

Methodology
Immunoassay (IA)

Setup Schedule

Set up: Daily; Report Available: 1-2 days

Reference Range

<3 Years	Not established
	Male (nmol/L)	Female (nmol/L)
3-9 Years	32-158	32-158
10-13 Years	20-166	24-120
14-17 Years	20-87	12-150
18-55 Years	10-50	17-124
>55 Years	22-77	14-73

Clinical Significance

Testosterone, dihydrotestosterone and estrogens circulate in serum bound to Sex Hormone Binding Globulin (SHBG). SHBG concentrations are increased in pregnancy, hyperthyroidism, cirrhosis, oral estrogen administration and by certain drugs. Concentrations are decreased by testosterone, hypothyroidism, Cushings syndrome, acromegaly and obesity.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.