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Growth Hormone Binding Protein (GH-BP)
Test CodeGHBP
Quest Code
37101
CPT Codes
83520<br><strong>** This test is not available for New York patient testing. **</strong>
Preferred Specimen
1 mL serum
Minimum Volume
0.2 mL
Transport Temperature
Frozen
Specimen Stability
Room temperature: 4 hours
Refrigerated: 6 hours
Frozen: 30 days
Refrigerated: 6 hours
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Received room temperature
Methodology
Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Pan Laboratories, Irvine,CA. This assay has been validated pursuant to the CLIA regulations. It has not been cleared or approved by the U.S.Food and Drug Administration.
Setup Schedule
Sets up 1 day a week.
Reference Range
| 3-8 Years | 320-3820 pmol/L |
| 9-13 Years | 240-2890 pmol/L |
| 14-17 Years | 290-3140 pmol/L |
| Adult | 400-4260 pmol/L |
Clinical Significance
Human growth hormone (GH) exists in several isomeric forms in serum, either free or bound to a specific binding protein(GH-BP).This protein is identical to extracellular domain of the GH receptor on the cell membrane. Level of GH-BP varies with age, being low in neonates and highest in young adults. Normal or elevated levels in patients with classical Laron syndrome indicate a defect in the transmembrane, intracellular or post translational GH receptor domains. Very low or absent GHBP denotes a defect in the extracellular domain. A low GH-BP in relatives of patients with Laron syndrome helps identify heterozygous carriers of patients with defects in the extracellular domain.
Performing Laboratory
Pan Laboratories, LLC
15375 Barranca Pkw, E101
Irvine, CA 92618
