Hantavirus Antibody (IgG, IgM)

Test Code

HANTA

Quest Code

37547

Alias/See Also

Hanta

CPT Codes
86790 (x2)

Includes

IgM positives will be reported to public health

Preferred Specimen

0.5 mL serum

Minimum Volume

0.1 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly hemolyzed, icteric, or lipemic samples

Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Sets up 6 days a week.

Reference Range

Hantavirus Ab (IgG)	Negative
Hantavirus Ab (IgM)	Negative

Clinical Significance

Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus (SNV), which causes hantavirus pulmonary syndrome, a severe and sometimes fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States. Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All Hanta IgM positive samples from US residents will be sent to a Public Health Laboratory for SNV-specific IgM. Samples that are Hanta IgG positive but IgM negative are not subjected to SNV-specific IgM testing, since the lack of IgM rules out acute SNV infection. A positive Hanta IgM result but a negative SNV-specific IgM antibody result may indicate either reactivity to a hantavirus other than SNV or false positive reactivity. A small number of SNV IgM postive (but Hanta IgG negative) samples represent false positive reactivity associated with acute cytomegalovirus or Epstein Barr virus infection.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.