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Ionized Calcium Level
MessageSpecimen must be tested within 30 minutes of draw. Unless kept at 0-4°C, then the specimen is stable for up to 3 days.
Test Code
ICA
Alias/See Also
Ionized Calcium
CPT Codes
82330
Preferred Specimen
Green top (Lithium Heparin) (can have gel - Do Not spin)
Minimum Volume
2 mL
Other Acceptable Specimens
SST
Instructions
Methodology
Potentiometric
Setup Schedule
Monday through Sunday; Continuously
Report Available
Same day
Reference Range
4.5-5.4 mg/dL
Critical value (automatic call-back): <3.3 or >6.0 mg/d
Critical value (automatic call-back): <3.3 or >6.0 mg/d
Clinical Significance
Ionized calcium measurements are used in the diagnosis, monitoring, and treatment of conditions including, but
not limited to, parathyroid disease, a variety of bone diseases, chronic renal disease, tetany, and disturbances
related to surgical and intensive care.
Measurements of ionized calcium have proven of value under the following clinical conditions: transfusion of
citrated blood, liver transplantation, open heart surgery, neonatal hypocalcemia, renal disease,
hyperparathyroidism, malignancy, hypertension and pancreatitis.
Although most of the calcium in blood is bound to protein or complexed to smaller anionic species, the biologically
active fraction of calcium is free ionized calcium. Through its role in a number of enzymatic reactions and in
membrane transport mechanisms, ionized calcium is vitally important in blood coagulation, nerve conduction,
neuromuscular transmission and in muscle contraction.
not limited to, parathyroid disease, a variety of bone diseases, chronic renal disease, tetany, and disturbances
related to surgical and intensive care.
Measurements of ionized calcium have proven of value under the following clinical conditions: transfusion of
citrated blood, liver transplantation, open heart surgery, neonatal hypocalcemia, renal disease,
hyperparathyroidism, malignancy, hypertension and pancreatitis.
Although most of the calcium in blood is bound to protein or complexed to smaller anionic species, the biologically
active fraction of calcium is free ionized calcium. Through its role in a number of enzymatic reactions and in
membrane transport mechanisms, ionized calcium is vitally important in blood coagulation, nerve conduction,
neuromuscular transmission and in muscle contraction.
Performing Laboratory
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