Syphilis Scrn w/rflx RPR and Titer, or TPPA

Test Code

SYPHTOT

Alias/See Also

Performed at MMC Micro for NOCO
Performed at SQL, Test Code 905363

CPT Codes
86780

Preferred Specimen

1.5 mL serum from a serum separator tube (SST). Centrifuge as soon as possible after clot formation. Due to potential assay inferference, do not collect samples from patients receiving high dose biotin therapy (i.e., >5mg/day) until at least 8 hours (optimally 24 to 72 hours) following the last dose.

Minimum Volume

1 mL

Instructions

For facilities sending to Sonora Quest Laboratories, see link below for specimen details, methodology, setup schedule and reference ranges.

Transport Temperature

Refrigerated

Specimen Stability

Ambient: 7 days
Refrigerated: 14 days
Frozen: 12 months

Methodology
Electrochemiluminescent Immunoassay (ECLIA)

Setup Schedule

Days, Evenings & Nights: Monday through Sunday

Report Available

1 day

Reference Range

Non-reactive

Clinical Significance

The reverse algorithm (Syphilis Screen w/rflx RPR and Titer or TPPA) begins with a treponemal specific antibody test, reactive results are confirmed with an RPR screen. If the RPR is positive, then it is an active infection. If the RPR is negative, then a secondary treponemal test (TP-PA) is employed. A positive TP-PA indicates a previously treated infection or latent syphilis; a negative suggests that syphilis screen was falsely positive and a syphilis infection is unlikely.

Performing Laboratory
Sonora Quest Laboratories or McKee Medical Center Microbiology Laboratory

Additional Information
Syphilis Scrn w/rflx RPR and Titer, or TPPA

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.