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Lactate Dehydrogenase (LD) Isoenzyme Panel

Message
Testing requires a dedicated tube. Cannot be combined with other testing. Specimen must be aliquoted off after centrifugation.


Test Code
LDISO


Quest Code
4411


Alias/See Also
4411


CPT Codes
83615, 83625

Includes
Lactate Dehydrogenase (LD)
Lactate Dehydrogenase Isoenzymes (LD1, LD2, LD3, LD4, LD5)


Preferred Specimen
2 mL serum


Minimum Volume
1 mL


Instructions
Centrifuge serum specimens within 1 hour of collection, transfer serum to a clean, plastic, transport tube(s), and transport at room temperature to the laboratory. Do not refrigerate or freeze the specimens.
Specimens cannot be shared, and no other tests should be ordered with Lactate Dehydrogenase Isoenzymes.


Transport Temperature

Room temperature



Specimen Stability

Room temperature: 7 days
Refrigerated: Unacceptable
Frozen: Unacceptable



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received refrigerated • Received frozen


Methodology
Electrophoresis • Spectrophotometry (SP)

Setup Schedule
Night Sets up 3 days a week.


Report Available
Reports in 2 to 3 days.


Reference Range
⁠⁠⁠⁠⁠⁠⁠Lactate Dehydrogenase (LD)
 Male (U/L)Female (U/L)
<1 Month125-735145-765
1-11 Months170-450190-420
1-3 Years155-345165-395
4-6 Years155-345135-345
7-10 Years140-270140-270
11-13 Years110-250110-250
14-17 Years110-230110-230
18-49 Years100-220100-200
>49 Years120-250120-250

Lactate Dehydrogenase Isoenzymes
LD118-32 %
LD229-42 %
LD314-30 %
LD46-13 %
LD55-18 %


Clinical Significance
Lactate dehydrogenase (LD) is present in many different organs and tissues such as liver, heart, muscles, kidney, lungs and blood. The usual designation of isoenzymes is LD-I, LD-II, LD-III, LD-IV and LD-V. LD isoenzymes tissue specificity is derived from the fact that LD subunits are synthesized in well-defined ratios and could be used in investigating unexplained causes of Total LD elevations and detection of macro-LD. Do not use LD isoenzymes to detect myocardial injury.


Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.