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Lactate Dehydrogenase (LD) Isoenzyme Panel
MessageTesting requires a dedicated tube. Cannot be combined with other testing. Specimen must be aliquoted off after centrifugation.
Test Code
LDISO
Quest Code
4411
Alias/See Also
4411
CPT Codes
83615, 83625
Includes
LD
LD Isoenzymes (LD1, LD2, LD3, LD4, LD5)
LD Isoenzymes (LD1, LD2, LD3, LD4, LD5)
Preferred Specimen
2 mL serum collected in a Serum Separator Tube (SST®)
Minimum Volume
1 mL
Instructions
Centrifuge serum specimen within 1 hour of collection, transfer serum to clean, plastic, screw-capped vial(s), and transport at room temperature to the laboratory. Do not refrigerate or freeze the specimens. Specimens cannot be shared, and no other tests should be ordered with Lactate Dehydrogenase Isoenzymes.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received refrigerated • Received frozen
Methodology
Electrophoresis • Spectrophotometry (SP)
Setup Schedule
Night Sets up 3 days a week.
Report Available
Reports in 2 to 3 days.
Reference Range
See Laboratory Report
Clinical Significance
Lactate dehydrogenase (LD) is present in many different organs and tissues such as liver, heart, muscles, kidney, lungs and blood. The usual designation of isoenzymes is LD-I, LD-II, LD-III, LD-IV and LD-V. LD isoenzymes tissue specificity is derived from the fact that LD subunits are synthesized in well-defined ratios and could be used in investigating unexplained causes of Total LD elevations and detection of macro-LD. Do not use LD isoenzymes to detect myocardial injury.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130