Soluble Liver Antigen (SLA) Autoantibody

Test Code

ASLA

Quest Code

38928

Alias/See Also

38928

CPT Codes
83520

Preferred Specimen

1 mL serum

Minimum Volume

0.3 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 8 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Lipemia

Methodology
Immunoassay (IA)

Setup Schedule

A.M. Sets up 1 day a week.

Report Available

Maximum Laboratory Turn Around Time 8 days.

Reference Range

<20.1 U	Negative
20.1-24.9 U	Equivocal
≥25.0 U	Positive

Clinical Significance

Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.