Thyroid Function Panel

TSHRFLX - NOCO

TSH W/Reflex Free T4

In-patient: 1 mL plasma from Green top (Lithium Heparin)
Out-patient: 1 mL serum from SST

Temperature	Time
Ambient	5 days
Refrigerated	5 days

TSH
0 - 4 days: 3.20 - 35.00 mIU/L
4 days - 1 month: 1.70 - 9.10 mIU/L
1 month - 1 years: 0.80 - 8.20 mIU/L
1 - 6 years: 0.60 7.40 mIU/L
6 - 11 years: 0.50 - 5.40 mIU/L
11 - 20 years: 0.30 - 4.00 mIU/L
20 - 150 years: 0.45 - 4.50 mIU/L

FT4
0 - 31 days: 0.8 - 2.2 ng/mL
31 days - 7 months: 0.8 - 1.8 ng/mL
7 months - 1 year: 0.8 1.6 ng/mL
1 - 7 years: 0.9 - 1.4 ng/mL
7 - 12 years: 0.9 - 1.6 ng/mL

TSH is formed in specific basophil cells of the anterior pituitary and is subject to a circadian secretion sequence. The hypophyseal release of TSH (thyrotropic hormone) is the central regulating mechanism for the biological action of thyroid hormones. TSH has a stimulating action in all stages of thyroid hormone formation and secretion; it also has a proliferative effect. The germination of TSH serves as the initial test in thyroid diagnostics. Even very slight changes in the concentrations of the free thyroid hormones bring about much greater opposite changes in the TSH level. Accordingly, TSH is a very sensitive and specific parameter for assessing thyroid function and is particularly suitable for early detection or exclusion of disorders in the central regulating circuit between the hypothalamus, pituitary and thyroid. Thyroxine (T4) is the main thyroid hormone secreted into the bloodstream by the thyroid gland. Together with triiodothyronine (T3) it plays a vital role in regulating the body’s metabolic rate, influences the cardiovascular system, growth and bone metabolism, and is important for normal development of gonadal functions and nervous system. T4 circulates in the bloodstream as an equilibrium mixture of free and serum bound hormone. Free T4 (fT4) is the unbound and biologically active form, which represents only 0.03% of the total T4. The remaining T4 is inactive and bound to serum proteins such as thyroxine binding globulin (75%), pre-albumin (15%), and albumin (10%). The determination of free T4 has the advantage of being independent of changes in the concentrations and binding properties of the binding proteins; additional determination of a binder parameter (T-uptake, TBG) is therefore unnecessary. Therefore, free T4 is a useful tool in clinical routine diagnostics for the assessment of the thyroid status. It should be measured together with TSH if thyroid disorders are suspected and is also suitable for monitoring thyrosuppressive therapy.