| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cancer Antigen 125 (CA 125)
Test CodeCA125. - NCMC
CPT Codes
86304
Preferred Specimen
1.0 mL serum from SST
Minimum Volume
0.5 mL
Other Acceptable Specimens
1 mL plasma from Green top (Lithium Heparin) or 1 ml serum from Red Top
Specimen Stability
| Specimen Type | Temperature | Time |
| Serum SST | Refrigerated | 5 days |
| Frozen | 6 months | |
| Red Top – Separated* | Refrigerated | 5 days |
| Frozen | 6 months | |
| Plasma Li Hep | Refrigerated | 5 days |
| Frozen | 6 months |
*Centrifuge and aliquot into a plastic vial.
Methodology
Chemiluminescent immunoassay.
Setup Schedule
Monday through Sunday; Continuously
Report Available
Same day
Reference Range
| Age | |
| 0 – 4 months | 2.4 – 22.0 |
| 4 months – 5 years | 7.7 – 33.0 |
| 5 years – 11 years | 4.7 – 30.0 |
| 11 years – 19 years | 5.9 – 39.0 |
| 19 years – 150 years | < 38.1 |
Clinical Significance
CA 125 belongs to the family of hybridoma defined tumor markers. The values measured are defined by the use of the monoclonal antibody (MAb) OC 125.
Elevated values are sometimes found in various benign gynecological diseases such as ovarian cysts, ovarian metaplasia, endometriosis, uterus myomatosus or cervicitis. Slight elevations of this marker may also occur in early pregnancy and in various benign diseases (e.g. acute and chronic pancreatitis, benign gastrointestinal diseases, renal insufficiency, autoimmune diseases and others). Markedly elevated levels have been found in benign liver diseases such as cirrhosis and hepatitis. Extreme elevations can occur in any kind of ascites due to malignant and benign diseases. Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract and various other malignancies.
Elevated values are sometimes found in various benign gynecological diseases such as ovarian cysts, ovarian metaplasia, endometriosis, uterus myomatosus or cervicitis. Slight elevations of this marker may also occur in early pregnancy and in various benign diseases (e.g. acute and chronic pancreatitis, benign gastrointestinal diseases, renal insufficiency, autoimmune diseases and others). Markedly elevated levels have been found in benign liver diseases such as cirrhosis and hepatitis. Extreme elevations can occur in any kind of ascites due to malignant and benign diseases. Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract and various other malignancies.
Performing Laboratory
North Colorado Medical Center Laboratory
