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Alkaline Phosphatase
MessageMeasurements of serum alkaline phosphatase (ALP) are used in the diagnosis of hepatobiliary disorders and bone disease associated with increased osteoblastic activity. Certain conditions such as Hodgkin's Disease, congestive heart failure and ulcerative colitis will produce moderate elevation in ALP levels. Non-pathologic elevations can be observed in the third trimester of pregnancy.
Test Code
ALP
Alias/See Also
LAB3000015
ALP
ALP
CPT Codes
84075
Preferred Specimen
2.0 mL serum collected in serum seperator tube (SST)
Patient Preparation
None
Minimum Volume
0.5 mL serum
Other Acceptable Specimens
2.0 mL serum collected in rapid clot tube (RCT)
2.0 mL plasma collected in lithium heparin plasma seperator tube (PST)
2.0 mL plasma collected in lithium heparin plasma seperator tube (PST)
Instructions
Serum or plasma should be separated from the cells within two hours of collection
Specimen Stability
4 days when stored Refrigerated (2-8oC)
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
The ALP procedure is based on the method developed by Bowers and McComb and has been formulated as recommended by the AACC and IFCC3.
Reference Range
| Sex | Age | Reference Range |
|---|---|---|
| M/F | 0 - 1 month | 90 - 270 U/L |
| M/F | 1 month - 3 years | 145 - 320 U/L |
| M/F | 3 - 6 years | 150 - 380 U/L |
| M/F | 6 - 9 years | 175 - 420 U/L |
| M | 9 - 11 years | 135 - 530 U/L |
| F | 9 - 11 years | 130 - 560 U/L |
| M | 11 - 13 years | 200 - 476 U/L |
| F | 11 - 13 years | 105 - 410 U/L |
| M | 13 - 15 years | 130 - 448 U/L |
| F | 13 - 15 years | 70 - 252 U/L |
| M | 15 - 19 years | 65 - 260 U/L |
| F | 15 - 19 years | 50 - 130 U/L |
| M/F | 19 - 64 years | 34 - 104 U/L |
| M | 65 - 150 years | 34 - 104 U/L |
| F | 65 - 150 years | 34 - 144 U/L |
Performing Laboratory
Penn Medicine Lancaster General Health
