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HCV NS3/4A Protease Inhibitor Resistance
MessageARUP test number: 3001234
(This test should be ordered by University of Pennsylvania Transplant providers ONLY)
(This test should be ordered by University of Pennsylvania Transplant providers ONLY)
Test Code
PNS34
Alias/See Also
0001196, 0001196
CPT Codes
87900; 87902
Includes
EER HCV GenoSure NS3 and NS4A
HCV GenoSure NS3 and NS4A
HCV GenoSure NS3 and NS4A Interpretation
HCV GenoSure NS3 and NS4A
HCV GenoSure NS3 and NS4A Interpretation
Preferred Specimen
2 mL plasma from Lavender (EDTA)
Patient Preparation
Procedure should be used for patients with HCV genotype (subtype) 1a or 1b and a viral load greater than 2000 IU/mL.
Minimum Volume
1 mL plasma
Instructions
Separate from cells within 6 hours of collection. Transfer 2 mL plasma and freeze immediately.
Transport Temperature
Frozen
Specimen Stability
Ambient: Unacceptable
Refrigerated: Unacceptable
Frozen: 2 weeks
Refrigerated: Unacceptable
Frozen: 2 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Thawed specimens
Methodology
Polymerase Chain Reaction/Sequencing
Report Available
10 to 17 days
Reference Range
See Patient Report for Reference Range and/or Interpretation of Results
Clinical Significance
Recommended testing for HCV genotype 1 patients prior to initiating simeprevir therapy. Identifies the Q80K polymorphism.
Performing Laboratory
ARUP Laboratory sends testing to Monogram Biosciences
