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Factor II Prothrombin 20210A Mutation Analysis
Test CodeFACT2
Alias/See Also
LAB0000122
CPT Codes
81240
Preferred Specimen
5mL whole blood collected in EDTA (lavender-top) tube
Minimum Volume
3mL
Transport Temperature
Room Temperature
Specimen Stability
Room temperature: 24 hours
Refrigerated: 15 days
Frozen:3 months
Refrigerated: 15 days
Frozen:3 months
Methodology
polymerase chain reaction (PCR)
Setup Schedule
Daily.
Report Available
Same day
Clinical Significance
The association of Factor II (G20210A) mutations with an increased risk for venous thrombosis has been well documented.
Factor II c.*97G>A was previously designated as G20210A or 20210G>A4 and is commonly referred to as prothrombin or, as in the Xpert Factor II & Factor V test, as Factor II (G20210A). The Factor II (G20210A) mutation refers to the G to A transition at nucleotide 20210 in the 3' untranslated region of the gene and is associated with increased plasma levels of prothrombin.
Factor II (G20210A) mutations are present in 2% of the general population.
Factor II c.*97G>A was previously designated as G20210A or 20210G>A4 and is commonly referred to as prothrombin or, as in the Xpert Factor II & Factor V test, as Factor II (G20210A). The Factor II (G20210A) mutation refers to the G to A transition at nucleotide 20210 in the 3' untranslated region of the gene and is associated with increased plasma levels of prothrombin.
Factor II (G20210A) mutations are present in 2% of the general population.
Performing Laboratory
Penn Medicine Lancaster General Health
