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Cystatin C with Glomerular Filtration Rate, Estimated
Test CodeCYSTG
Alias/See Also
LAB0001220
Cystatin C with Glomerular Filtration Rate, Estimated
Cystatin C with Glomerular Filtration Rate, Estimated
CPT Codes
85730
Includes
Cystatin C, Estimated Glomerular Filtration Rate
Preferred Specimen
1.0mL Serum, collected in a serum separator tube (SST)
Minimum Volume
0.5mL Serum
Other Acceptable Specimens
Plain Red Top or Orange Rapid Clot Tube
Transport Temperature
Room Temperature or Refrigerated
Specimen Stability
14 days room temperature (8-25°C)
21 days refrigerated (2-8°C)
Samples are only kept for 72 hours for add-on testing. Please call the lab to determine if sample is available for add on testing.
21 days refrigerated (2-8°C)
Samples are only kept for 72 hours for add-on testing. Please call the lab to determine if sample is available for add on testing.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
PETIA (Particle-enhanced turbidimetric immunoassay)
FDA Status
Approved
Report Available
Same Day
Limitations
The Cystatin C GFR calculation should only be performed on patients above 14 years of age.
Reference Range
| Sex | Age | Reference Range |
|---|---|---|
| M/F | 0 - 150Y | 0.51 - 1.05mg/L |
Clinical Significance
The Gentian Cystatin C Immunoassay is an in vitro diagnostic test for quantitative determination of cystatin C in human serum and plasma. The measurement of cystatin C is used in the diagnosis and treatment of kidney disease.
The non-glycosylated basic protein, cystatin C (molecular weight 13.2 kD), is produced at a constant rate in nearly every nucleated cell in the human body. It is freely filtered through a normal glomerular membrane and is then reabsorbed and almost entirely catabolized in the proximal tubules. Hence, the cystatin C concentration in human blood is closely related to glomerular filtration rate (GFR). A reduction in the GFR causes a rise in the concentration of cystatin C.
The non-glycosylated basic protein, cystatin C (molecular weight 13.2 kD), is produced at a constant rate in nearly every nucleated cell in the human body. It is freely filtered through a normal glomerular membrane and is then reabsorbed and almost entirely catabolized in the proximal tubules. Hence, the cystatin C concentration in human blood is closely related to glomerular filtration rate (GFR). A reduction in the GFR causes a rise in the concentration of cystatin C.
Performing Laboratory
Penn Medicine Lancaster General Health
