HPV, High Risk

Message

Intended for the detection of high risk human papillomavirus (HPV) in cervical specimens
Auto reflexing to genotyping of HPV 16, 18/45

Test Code

HPVHI

Alias/See Also

0000288, 0000288

CPT Codes
87624, 87624

Includes

HPVNO, HVHI

Preferred Specimen

Thin Prep vial

Minimum Volume

1 Thin Prep vial

Instructions

Cervical specimens in Thin Prep Pap test vial containing PreservCyt Solution and collected with broom-type or cytobrush/spatula collection devices may be tested.

Transport Container

Thin Prep vial

Transport Temperature

Room temperature or refrigerated

2°C-30°C

Specimen Stability

Room Temperature: 30days
Refrigerated: 90days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Frozen sample

Methodology
Transcription Mediated Amplification (TMA)

Setup Schedule

Monday-Friday

Reference Range

See patient report for interpretation of results.

Clinical Significance

HPV mRNA E6/E7 - The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6-E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management

Performing Laboratory
Penn Medicine Lancaster General Hospital

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.