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Fetal Fibronectin
Test CodeFFN
Alias/See Also
LAB3180621
CPT Codes
82731
Preferred Specimen
Hologic Collection kits will be provided by the WBH Lab. They can be reached at 717-544-3303.
Instructions
- Sample must be collected in Hologic FFN Test Collection Kit and transported to the lab at 2 to 25° C.
- Specimens not tested within 8 hours of collection must be stored refrigerated at 2 to 8° C
- The specimen should be collected prior to a digitial cervical exam, collection of culture specimens, or vaginal probe ultrasound exams.
- Do not contaminate the swab or specimen with lubricants, soapr, disinfectants, or creams.
- Do not collect specimen if patient has had sexual intercourse within 24 hours prior to sampling, moderate to gross vaginal bleeding, advanced cervical dilation, ruputure of membranes, gestational agebefore 22 weeks or after 35 weeks, or suspected or known placental abruption or placenta previa.
Transport Container
Adeza Biomedical Specimen Collection Kit
Transport Temperature
Collection Kit and transported to the lab at 2 to 25° C. Specimens not tested within 8 hours of collection must be stored refrigerated at 2 to 8° C.
Specimen Stability
Collection Kit and transported to the lab at 2 to 25° C. Specimens not tested within 8 hours of collection must be stored refrigerated at 2 to 8° C.
Methodology
Solid Phase Immunosorbent Colorimetric Assay
Setup Schedule
Tests are processed 24 hours a day, 7 days a week.Results will be available within 3 hours of specimen receiptin laboratory.
Limitations
The Fetal Fibronectin test result should not be interpreted as absolute evidence for the presence or absence of a process that will result in delivery in ≤7 days from specimen collection for symptomatic women or ≤34 weeks, 6 days of gestation for asymptomatic women. A positive Fetal Fibronectin Enzyme Immunoassay or Rapid fFN result may be observed for patients who have experienced cervical disruption caused by, but not limited to, events such as sexual intercourse, digital cervical examination, or vaginal probe ultrasound. The test sensitivity is 86.4%, specificity is 82.3%, positive predictive value is 12.7%, and negative predictive value is 99.5% in symptomatic women.
Reference Range
Negative
Clinical Significance
Fetal fibronectin is a protein that performs two roles during pregnancy. It is produced by the placenta and acts as the glue that attaches the placenta to the uterine wall. In late pregnancy, it acts as a lubricant, aiding in the passage of the newborn through the vaginal canal. Amniotic fluid contains fetal fibronectin and when the membranes leak, can be detected in a cervicovaginal collection. This can be used as a predictor of pre-term delivery, defined as less than 37 weeks gestation.
Performing Laboratory
Penn Medicine Lancaster General Health
