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CSF 14-3-3 Protein
MessageSpecimen sent to:
National Prion Disease Pathology Surveillance Center
Case Western Reserve University
Clevland, OH
National Prion Disease Pathology Surveillance Center
Case Western Reserve University
Clevland, OH
Test Code
1433
Alias/See Also
1433
LAB0000667
LAB0000667
CPT Codes
0035U, 83520 (X2)
Preferred Specimen
5 mL CSF and 100-200 mL urine
Patient Preparation
Complete the National Prion Requsition "Test Request Form", available on the website at National Prion Disease Pathology Surveillance with the sample.
Instructions
Collect CSF by lumbar puncture. Discard first 2 mL that flows from tap. Collect next 5 mL CSF, avoiding bloody tap.
Freeze within 20 minutes of collection. Store and transport frozen. Ship using a styrofoam container with sufficient dry ice (5 lbs/24 hours). The NPDPSC requests a urine sample for research purposes with all CSF samples if available.
**Please note: Patient is also asked to submit a frozen urine sample (100-200 mL) for validation of a recently published diagnostic test on Creutzfeldt-Jakob disease; no report will be issued. Please inform patient and/or family that urine is used for research on a diagnostic test and obtain oral consent.
Freeze within 20 minutes of collection. Store and transport frozen. Ship using a styrofoam container with sufficient dry ice (5 lbs/24 hours). The NPDPSC requests a urine sample for research purposes with all CSF samples if available.
**Please note: Patient is also asked to submit a frozen urine sample (100-200 mL) for validation of a recently published diagnostic test on Creutzfeldt-Jakob disease; no report will be issued. Please inform patient and/or family that urine is used for research on a diagnostic test and obtain oral consent.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 24 hours
Refrigerated: 14 days
Frozen: Indefinitely
Refrigerated: 14 days
Frozen: Indefinitely
Methodology
Immunoassay
RT-QuIC
Setup Schedule
Tuesdays and Thursdays
Report Available
21 days
Reference Range
See Patient Report for Reference Ranges
Clinical Significance
Search for the presence of the 14-3-3 protein. The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded.
Performing Laboratory
National Prion Disease Pathology Surveillance Center
