Tropheryma whipplei DNA Detection by Rapid PCR (NY)

Test Code

CPT Codes

Preferred Specimen

5 mm fresh tissue, submitted in a sterile, plastic leakproof container
Specimens grossly contaminated with blood may inhibit the PCR and produce false-negative results.


Other Acceptable Specimens
5 mm paraffin block; 0.5 mL synovial, vitreous, or spinal fluid submitted in a sterile plastic leakproof vial

Submit only 1 of the following specimens:
Specimen Type: Biopsy
Sources: Preferred: Small intestine tissue (duodenum, ileum, or jejunum) Acceptable: Tissue or biopsy specimen of brain, gastrointestinal tissue, heart valve, lymph node, small intestine, synovial tissue, or other visceral tissue fixed in a paraffin block
Container/Tube: Sterile container
Specimen Volume:Entire collection
Collection Instructions: Collect fresh tissue specimen.
Specimen Type: Spinal, synovial, or vitreous humor fluid
Container/Tube: Sterile vial

Transport Container

Sterile Container, leak-proof
The high sensitivity of amplification by PCR requires the specimen to be processed in an environment in which contamination of the specimen by Tropheryma whipplei DNA is not likely.

Transport Temperature
Fresh Tissue (preferred): Frozen
Paraffin Block: Room temperature
Fluid: Refrigerated (cold packs)

Specimen Stability
Fresh Tissue:
Room temperature: Unacceptable
Refrigerated: 48 hours
Frozen: 7 days 

Parrafin Block:
Room temperature: indefinitely
Refrigerated: Indefinitely
Frozen: Indefinitely

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 7 days

Polymerase Chain Reaction

FDA Status
**This test is for New York State clients only. For non-New York State patient testing, use Test Code 11352X [11769] Tropheryma whipplei DNA Detection by Rapid PCR.

Setup Schedule
Set up: Mon, Wed, Fri a.m.; Report available: 9 days

Reference Range

See Laboratory Report

Clinical Significance
Test is used for the diagnosis of Whipple's disease, especially for identifying inconclusive or suspicious cases.

Performing Laboratory
Mayo Medical Laboratories
200 First Street SW
Rochester, MN 55905

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.