| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
MSH6, IHC without Interpretation
Test Code16252
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged tissue slides
Instructions
Do not freeze
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemical Stain
Setup Schedule
Set up: Mon-Fri a.m.; Report available: Next day
Reference Range
See Laboratory Report
Clinical Significance
MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as hereditary non-polyposis colon cancer (HNPCC). This assay is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
