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CD21, IHC with Interpretation [40037X]
Test Code40037
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged tissue slides
Instructions
Please include the surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri a.m.; Report available: 2 days
Reference Range
Interpretive report
Clinical Significance
CD21 antigen is a type I integral membrane glycoprotein
of molecular weight 140 kD, which functions as the
receptor for the C3d fragment of the third complement
component. The CD21 molecule, present on mature B cells,
is involved in trasmitting growth-promoting signals to
the interior of the B cell and acts as a receptor for
Epstein-Barr virus.
CD21 antigen is reported to be found in B cell chronic
lymphocytic leukemias and in a subset of T cell acute
lymphocytic leukemias, but is absent on T lymphocytes,
monocytes, and granulocytes. CD21 antigen is also
reported to be expressed in follicular dendritic cells
and in follicular and centrocytic lymphomas, mature
leukemias and lymphomas, and at high density in
follicular dendretic cells.
of molecular weight 140 kD, which functions as the
receptor for the C3d fragment of the third complement
component. The CD21 molecule, present on mature B cells,
is involved in trasmitting growth-promoting signals to
the interior of the B cell and acts as a receptor for
Epstein-Barr virus.
CD21 antigen is reported to be found in B cell chronic
lymphocytic leukemias and in a subset of T cell acute
lymphocytic leukemias, but is absent on T lymphocytes,
monocytes, and granulocytes. CD21 antigen is also
reported to be expressed in follicular dendritic cells
and in follicular and centrocytic lymphomas, mature
leukemias and lymphomas, and at high density in
follicular dendretic cells.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
