CD21, IHC with Interpretation [40037X]

Test Code

40037

CPT Codes
88342

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue block submitted in an IHC Specimen Transport Kit

Other Acceptable Specimens

3 unstained, positively charged tissue slides

Instructions

Please include the surgical pathology report

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Methodology
Immunohistochemistry (IHC)

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 2 days

Reference Range

See Laboratory Report

Clinical Significance

CD21 antigen is a type I integral membrane glycoprotein of molecular weight 140 kD, which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells, is involved in trasmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias, but is absent on T lymphocytes, monocytes, and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and centrocytic lymphomas, mature leukemias and lymphomas, and at high density in follicular dendretic cells.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.