Acetylcholine Receptor Binding Antibody with Reflex to MuSK Antibody

Test Code

CPT Codes

If Acetylcholine Receptor Binding Antibody is Negative, then MuSK Antibody Test will be performed at an additional charge (CPT cod(s): 83519)

Preferred Specimen
2 mL serum

Minimum Volume
0.5 mL

Allow blood to clot at room temperature. Serum should be separated from cells within one hour.

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Transport Container
Transport tube

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Microbially contaminated

Radioimmunoassay (RIA)

Setup Schedule
Set up: Daily p.m.; Report available: 8-15 days

Reference Range
See Laboratory Report

Clinical Significance
Anti-acetylcholine receptor binding antibodies (anti-AChR) are associated with Myasthenia Gravis (MG) and are found in approximately 85% of MG patients. Approximately 8% to 10% of all MG cases and 20% to 50% of generalized MG cases who lack anti-AChR antibodies have autoantibodies against muscle-specific kinase (anti-MuSK).

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.