Hepatocellular Carcinoma Panel

Test Code

16222

CPT Codes
82107, 83951

Includes

Alpha-Fetoprotein (AFP), AFP-L3, DCP (Des-Gamma-Carboxy-Prothrombin)

Preferred Specimen

2 mL serum

Minimum Volume

1 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

Room temperature: 48 hours
Refrigerated: 5 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemia • Heavy, visible particulate matter • Icteric

Methodology
Liquid-Phase Binding Assay System • Immunoassay (IA)

Setup Schedule

Setup: Tues a.m.; Report available: 3 days

Reference Range

AFP	1.6-4.5	ng/mL
AFP-L3	0.5-9.9	%
DCP	<7.5	ng/mL

Clinical Significance

HCC Risk Panel includes serum AFP-L3%, total AFP and DCP. The combined measurement helps discriminate benign and malignant conditions related to primary liver diseases [1-4]. Furthermore, the combination measurement of three HCC biomarkers can identify a greater number of patients at risk of developing HCC than with each marker alone.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.