IGF Binding Protein-1 (IGFBP-1)

Test Code

36590

CPT Codes
83519

Preferred Specimen

1 mL serum

Patient Preparation
Overnight fasting is preferred.

Minimum Volume

0.2 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Gross lipemia • Plasma

Methodology
Radioimmunoassay (RIA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues a.m.; Report available: 4-10 days

Reference Range

Adults	5-34 ng/mL
Pediatric
5-9 Years	15-95 ng/mL
10-14 Years	8-64 ng/mL
15-18 Years	5-40 ng/mL

Clinical Significance

The concentration of IGFBP-1 is correlated with glycemic conditions. IGFBP-1 may be used for monitoring insulin responsiveness, as a marker for insulin-producing tumors, monitoring acute fluctuations in insulin action, and determining if poor glycemic control is due to inadequate insulin treatment or poor control of dietary intake.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.