PD-1, IHC without Interpretation

Test Code

91323

CPT Codes
88342

Preferred Specimen

1 formalin-fixed, paraffin-embedded tissue block

Minimum Volume

1 Block

Other Acceptable Specimens

3 unstained, (+) charged slides, submitted in IHC Specimen Transport Kit

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received frozen

Methodology
Immunohistochemistry (IHC)

Setup Schedule

Setup: Mon-Fri a.m.; Report available: Next day

Reference Range

See Laboratory Report

Clinical Significance

The programmed death-1 (PD1) protein is expressed by follicular helper T-cells and is useful in the diagnosis of T-cell lymphomas and in highlighting L&H cells in Hodgkin lymphoma. Anti-PD-1 antibody has been used as anti-tumor immunotherapy agents. This effect is possibly due to the targeting of PD1 expressing tumor-infiltrating lymphocytes which can be enumerated by this antibody.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.