| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Porphyrins, Fractionated, Plasma
Test Code5519
CPT Codes
82542
Includes
Uroporphyrin, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Coproporphyrin, Protoporphyrin, Total Porphyrins
Preferred Specimen
2 mL plasma collected in a sodium heparin (green-top) tube - light protected
Minimum Volume
0.6 mL
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube - light protected • Serum collected in a red-top tube (no gel) - light protected
Instructions
Collect blood sample with foil-wrapped green-top tube. Separate plasma by centrifugation. Avoid hemolysis. Remove plasma to a light-protected tube. Freeze immediately after separation.
Transport Container
Plastic screw-cap vial, protected from light
Transport Temperature
Frozen
Specimen Stability
Room temperature: 8 hours
Refrigerated: 8 hours
Frozen: 90 days
Refrigerated: 8 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST)
Methodology
High Performance Liquid Chromatography (HPLC)
Setup Schedule
Set up: Sun, Wed; Report available: 6-11 days
Reference Range
| Uroporphyrin | ≤0.2 mcg/L |
| Heptacarboxyporphyrin | ≤0.2 mcg/L |
| Hexacarboxyporphyrin | ≤0.3 mcg/L |
| Pentacarboxyporphyrin | ≤0.4 mcg/L |
| Coproporphyrin | ≤0.8 mcg/L |
| Protoporphyrin | 0.4-4.8 mcg/L |
| Total Porphyrins | 1.0-5.6 mcg/L |
Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyrias and excluding porphyrias in patients with chronic renal failure suspected of having a porphyria.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
