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ALK (D5F3) with Interpretation by Immunohistochemistry
Test Code36928
CPT Codes
88342
Preferred Specimen
Formalin fix (10% neutral buffered formalin) tumor tissue block, and paraffin-embedded tumor tissue block in tissue transport kit (ARUP supply #47808)
Other Acceptable Specimens
5 unstained (3-5 micron thick sections), positively charged slides submitted in a tissue transport kit (ARUP supply #47808)
Instructions
Protect paraffin block and/or slides from excessive heat. If sending precut slides, do not oven bake.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Paraffin block with no tumor tissue remaining • Specimens fixed in any fixative other than 10 percent neutral buffered formalin
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri; Report available: 1-5 days
Reference Range
See Laboratory Report
Clinical Significance
Determine eligibility for tyrosine kinase inhibitor (TKI) therapy, primarily in individuals with pulmonary adenocarcinomas. Detects ALK fusion proteins.
Performing Laboratory
ARUP
500 Chipeta Way
Salt Lake City, UT 84108