A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
DOG1, IHC without Interpretation
Test Code90211
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively (+) charged slides
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Clinical Significance
DOG1 antibodies detect anoctamin 1, a marker of gastrointestinal stromal tumors that may be more sensitive (85-90% immunoreactive) than c-KIT antibodies (approximately 75%) or CD34 (approximately 70%), especially in the PDGFRA-mutated subgroup of GISTs. It is especially useful in the differential diagnosis with leiomyosarcoma and synovial sarcomas, which are nearly always negative for DOG1.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |