DOG1, IHC with Interpretation

Test Code

90161

CPT Codes
88342

Preferred Specimen

1 formalin-fixed, paraffin-embedded, tissue block

Other Acceptable Specimens

3 unstained slides, positively charged, submitted in an IHC Specimen Transport Kit

Instructions

Please include surgical pathology report.

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Methodology
Immunohistochemistry

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 3 days

Reference Range

Interpretive report

Clinical Significance

DOG1 antibodies detect anoctamin 1, a marker of gastrointestinal stromal tumors that may be more sensitive (85-90% immunoreactive) than c-KIT antibodies (approximately 75%) or CD34 (approximately 70%), especially in the PDGFRA-mutated subgroup of GISTs. It is especially useful in the differential diagnosis with leiomyosarcoma and synovial sarcomas, which are nearly always negative for DOG1.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.