Chromosome Analysis, Mosaicism

Test Code

14597

CPT Codes
88230, 88263

Includes

This test may be replaced by Chromosome Analysis, Blood, No Growth if cultures do not yield metaphases for analysis or by a Cytogenetics Communication if a communication is required.

Preliminary results available for neonatal specimens three days after receipt.

Preferred Specimen

5 mL whole blood collected in sodium heparin (green-top) tube, or sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL

Instructions

Clinical history/reason for referral is required with test order.

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Karyotype • Microscopy • Tissue Culture

Setup Schedule

Set up: Daily; Report available: 10 days

Reference Range

See Laboratory Report

Clinical Significance

This chromosome study will examine 50 metaphase cells, whereas a standard chromosome analysis will examine 20 metaphase cells. This test for mosaicism is used to assess for constitutional chromosomal mosaicism or chimerism. While standard chromosome analysis can detect mosaicism ≥14%, this test can detect mosaicism ≥6% (at a 95% confidence level).

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.