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Industrial Cadmium Screen
Test Code8887
CPT Codes
82232, 82300 (x2), 82570
Includes
Beta-2-Microglobulin, Urine
Cadmium, Blood
Cadmium, Urine
Creatinine, Random Urine
Cadmium, Blood
Cadmium, Urine
Creatinine, Random Urine
Preferred Specimen
4 mL whole blood collected in an EDTA (royal blue-top) tube or sodium heparin (royal blue-top) tube and
7 mL random urine collected in an acid-washed or metal-free container and
10 mL random urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport tube (available through Client Supply)
7 mL random urine collected in an acid-washed or metal-free container and
10 mL random urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport tube (available through Client Supply)
Minimum Volume
2 mL whole blood • 3 mL urine in an acid-washed or metal-free container • 10 mL urine in Beta-2 Microglobulin tube
Other Acceptable Specimens
See Collection Instructions
Instructions
Three separate collections are required. One collection of blood and two separate collections of urine.
Specimen 1: One EDTA or sodium heparin (royal blue-top) tube of whole blood.
Specimen 2: For urine cadmium and creatinine: collect urine in an acid washed or metal free plastic container. Label as Cadmium/Creatinine.
Specimen 3: For Urine Beta-2 Microglobulin: Once patient has voided bladder for cadmium/creatinine collection.
1. Patient should void bladder, then drink at least 500 mL (approximately 17 oz) of water.
2. A urine sample should be collected within 1 hour.
3. Pour exactly 10 mL of random urine into a Quest Diagnostics Beta-2 Microglobulin Transport Tube (available through Client Supply).
4. Ship Room temperature.
5. Alternatively, if the collection tubes are not available, pH of the specimen must be adjusted to between 6 and 8 using 1N NaOH prior to shipping.
Beta-2 Microglobulin in urine is unstable in acidic urine (less than pH 6). Exactly 10 mL of urine in the Quest Diagnostics Beta-2 Microglobulin Transport Tube is required to achieve the required pH of between 6 and 8. Any volume of urine above or below 10 mL will result in a pH that is outside the acceptable range.
Specimen 1: One EDTA or sodium heparin (royal blue-top) tube of whole blood.
Specimen 2: For urine cadmium and creatinine: collect urine in an acid washed or metal free plastic container. Label as Cadmium/Creatinine.
Specimen 3: For Urine Beta-2 Microglobulin: Once patient has voided bladder for cadmium/creatinine collection.
1. Patient should void bladder, then drink at least 500 mL (approximately 17 oz) of water.
2. A urine sample should be collected within 1 hour.
3. Pour exactly 10 mL of random urine into a Quest Diagnostics Beta-2 Microglobulin Transport Tube (available through Client Supply).
4. Ship Room temperature.
5. Alternatively, if the collection tubes are not available, pH of the specimen must be adjusted to between 6 and 8 using 1N NaOH prior to shipping.
Beta-2 Microglobulin in urine is unstable in acidic urine (less than pH 6). Exactly 10 mL of urine in the Quest Diagnostics Beta-2 Microglobulin Transport Tube is required to achieve the required pH of between 6 and 8. Any volume of urine above or below 10 mL will result in a pH that is outside the acceptable range.
Transport Temperature
Whole blood or urine in acid-washed container: Refrigerated (cold packs)
Urine in Microglobulin tube: Room temperature
Urine in Microglobulin tube: Room temperature
Specimen Stability
Whole blood
Room temperature: 48 hours
Refrigerated: 5 days
Frozen: Unacceptable
Cadmium & Creatinine Urine
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 14 days
Beta-2 Microglobulin Urine
Room temperature: 5 days
Refrigerated: 15 days
Frozen: 30 days
Room temperature: 48 hours
Refrigerated: 5 days
Frozen: Unacceptable
Cadmium & Creatinine Urine
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 14 days
Beta-2 Microglobulin Urine
Room temperature: 5 days
Refrigerated: 15 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Beta-2 Microglobulin: Specimens received in a non-Beta-2 Microglobulin transport tube with a pH <6 • Any volume other than 10 mL urine in the transport tube • Any specimen with pH <6
Methodology
Colorimetric (C) • Inductively Coupled Plasma/Mass Spectrometry (ICP/MS) • Kinetic • Nephelometry
Setup Schedule
Set up: Tues-Sat; Report available: 3 days
Reference Range
See individual tests
Clinical Significance
This panel is used for monitoring workers for potential exposure to cadmium in the workplace. The beta-2-microglobulin, blood and urine cadmium are integrated to specify the exposure category.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
