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Autoimmune Cerebellar Ataxia Panel
Test Code90133
CPT Codes
82784, 86596, 86364, 86255
Includes
Yo Antibody Screen with Reflex to Titer and Western Blot
Voltage-Gated Calcium Channel (VGCC) Type P/Q Antibody
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Yo Antibody, IFA, Serum is positive, then Yo Antibody, Western Blot, Serum will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, Serum is positive, then Yo Antibody, Titer, Serum will be performed at an additional charge (CPT code(s): 86256).
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If IgA, Serum is abnormal, then tTG (IgG) will be performed at an additional charge (CPT code(s): 86364).
Voltage-Gated Calcium Channel (VGCC) Type P/Q Antibody
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Yo Antibody, IFA, Serum is positive, then Yo Antibody, Western Blot, Serum will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, Serum is positive, then Yo Antibody, Titer, Serum will be performed at an additional charge (CPT code(s): 86256).
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If IgA, Serum is abnormal, then tTG (IgG) will be performed at an additional charge (CPT code(s): 86364).
Preferred Specimen
3 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
0.9 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Microbially contaminated serum • Specimens containing visible particles • Heat inactivated samples • Plasma
Methodology
Immunoassay (IA) • Immunofluorescence Assay (IFA) • Immunoturbidometry • Radiobinding Assay (RBA)
Setup Schedule
Set up: Mon-Sat; Report available: Up to 3 days after set up (Varies with assay)
Reference Range
See Laboratory Report
Clinical Significance
Cerebellar ataxia may occur as a result of autoantibodies to cerebellar targets. These may include antibodies to the Purkinje cell antigen Yo, the voltage gated calcium channel (VGCC) or tissue transglutaminase (tTG). Glutin ataxia is associated with widespread tissue transglutaminase (tTG) IgA deposition around vessels in the cerebellum, pons, and medulla.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
