Beta-fibrinogen-455G>A Mutation

Test Code

16182

CPT Codes
81400<br />

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

3 mL

Other Acceptable Specimens

Whole blood collected in ACD solution A and B (yellow-top), lithium heparin (green-top), or sodium heparin (green-top) tube

Instructions

Normal phlebotomy procedure. Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Methodology
Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Thurs; Report available: 9 days

Limitations

This assay does not test for the presence of mutations in other regions of the FGB gene that could contribute to thrombosis or other disease. In addition, this assay does not test for non-genetic causes of thrombosis or disease. Some individuals with thrombosis or clotting disorders may have other chromosomal or DNA abnormalities not detected by this test.

Reference Range

See Laboratory Report

Clinical Significance

This test detects a polymorphism in the promoter region of the fibrinogen gene, -455G→A, which is associated with elevated plasma fibrinogen level, an independent predictor of coronary heart disease.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.