Tricyclic Antidepressants ID and Quantitation

Test Code

CPT Codes
80337, 80338, 80332 (HCPCS: G0480)

Amitriptyline, Nortriptyline, and Total
Imipramine, Desipramine, and Total
Doxepin, Nordoxepin, Total, and Grand Total
Clompiramine, Desmethylclomipramine, and Total

Preferred Specimen
3 mL serum collected in a red-top tube (no gel)

Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Minimum Volume
1.5 mL

Other Acceptable Specimens
Serum collected in: No additive, no preservative (royal blue-top) tube • Plasma collected in: EDTA (lavender-top) tube or lithium heparin (green-top) tube

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 8 hours
Refrigerated: 5 days
Frozen: Not established

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum separator tube (SST)

Chromatography/Mass Spectrometry

Setup Schedule
Monday-Saturday Morning
Report available: 4 Days

Reference Range

See Laboratory Report

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.