ANCA Screen with MPO and PR3, with Reflex to ANCA Titer

Test Code
70159


CPT Codes
86021 (x2), 86036

Includes
ANCA Screen with Reflex to ANCA Titer
Myeloperoxidase Antibody (MPO)
Proteinase-3 Antibody

If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).


Preferred Specimen
2 mL serum collected in a red-top tube (no gel)


Minimum Volume
0.8 mL


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic


Methodology
Immunoassay (IA)

Setup Schedule
Set up: Mon-Sat p.m.; Report available: 3-5 days


Reference Range
ANCA Screen Negative
  P-ANCA Titer <1:20
  C-ANCA Titer <1:20
  Atypical P-ANCA Titer <1:20

Myeloperoxidase Antibody
<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Proteinase-3 Antibody
<1.0 AI No antibody detected
≥1.0 AI Antibody detected


Clinical Significance
Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.